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LONGEVITY PROTOCOL DISCOVERY SET

4.7
4.7 out of 5
4.7 out of 5
(11,607)

Travel-size longevity protocol to cleanse, hydrate + firm.

  • Age-Reversal Peptide
  • Smoothing
  • Firming
  • Fine Lines
A One Skin skincare gift set arranged on a metallic silver pouch against a light blue gradient background. The set includes a white tube of serum, a white jar with a black lid, a white bottle with a black cap, and a clear bottle containing a golden liquid, all decorated with black ribbons printed with the brand name.
Limited Edition
LONGEVITY PROTOCOL DISCOVERY SET
LONGEVITY PROTOCOL DISCOVERY SET
LONGEVITY PROTOCOL DISCOVERY SET
A One Skin skincare gift set arranged on a metallic silver pouch against a light blue gradient background. The set includes a white tube of serum, a white jar with a black lid, a white bottle with a black cap, and a clear bottle containing a golden liquid, all decorated with black ribbons printed with the brand name.
Limited Edition
LONGEVITY PROTOCOL DISCOVERY SET
LONGEVITY PROTOCOL DISCOVERY SET
LONGEVITY PROTOCOL DISCOVERY SET

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Cleanse, deeply hydrate, and boost visible firmness with this complete travel size longevity system for face and body powered by our proprietary OS-01 Senescence-Blocking Peptide™—designed to go wherever the season takes you
  • Travel-Size OS-01 FACE RICH CREAM delivers lasting hydration while supporting skin's visible firmness, resilience, and density1
  • Travel-Size OS-01 BODY MOISTURIZER boosts barrier strength while visibly smoothing skin, targeting a root cause of crepiness and sagging2
  • Travel-Size OS-01 EYE CREAM improves elasticity and firmness while smoothing the appearance of fine lines and wrinkles3,4
  • Travel-Size PREP FACIAL CLEANSER gently cleanses and exfoliates to leave skin balanced, hydrated, and healthy-looking
  • Sleek, durable, and water-resistant, the travel bag is built to go wherever the season takes you—with a design as fit for your counter as it is your carry-on suitcase.
Clinical proof

OS-01 FACE RICH CREAM

  • 100% saw improved hydration after 6 weeks1
  • 93% agreed their skin retains hydration better over time1
  • 97% saw a reduced appearance of fine lines and wrinkles after 6 weeks1
  • 93% saw improved visible firmness after 6 weeks1
  • +38% increase in skin’s hydration after 12 weeks1

OS-01 EYE CREAM

  • +26% increase in elasticity after 3 months3
  • +27% increase in visible firmness after 12 months4
  • -18% reduction in the appearance of fine lines and wrinkles after 12 months4

OS-01 BODY MOISTURIZER

  • +41% increase in skin’s barrier resilience after 12 weeks2
  • +38% increase in hydration after 12 weeks2
  • 70% reported visibly smoother texture and improved general appearance2

The Clinical Studies

OS-01 FACE RICH CREAM: 12-Week Efficacy Study1

A 12-week, third-party, double-blind clinical study evaluated the effects of OS-01 FACE RICH CREAM in 29 female participants ages 43-65 with mild to moderate facial skin sagging, firming, contouring, nasolabial folds, and expression lines. Participants applied OS-01 FACE RICH CREAM 2x daily to their face and neck. Barrier function and hydration were measured with instrumental devices (Corneometer, TEWL measurement), while radiance, texture,and hydration were evaluated visually and tactilely by expert clinical graders. Participants also provided subjective assessments via a self-reported questionnaire.

The results after 6 weeks:

  • 100% saw improved hydration
  • 93% agreed their skin retains hydration better over time
  • 97% saw a reduced appearance of fine lines and wrinkles
  • 93% saw improved visible firmness and elasticity
  • 97% reported smoother, softer, more radiant skin

The results after 12 weeks:

  • +38% increase in skin’s hydration
  • 97% had more hydrated skin
  • 97% reported improved overall appearance
  • 90% reported more nourished skin with improved skin quality
  • +37% improvement in skin smoothness
  • 83% agree their skin looks, feels, and acts more youthful
  • 81% saw reduced visible redness and irritation
  • +13% increase in barrier strength

OS-01 BODY MOISTURIZER: 3-Month Efficacy Study2

A 12-week, double-blind, third-party clinical study evaluated the effects of OS-01 BODY MOISTURIZER on body skin hydration, barrier function, texture, and appearance. 60 participants were divided into two groups: one applied OS-01 BODY twice daily, while the other applied a placebo moisturizer twice daily. Hydration and trans-epidermal water loss (TEWL) were measured with instrumental devices (Corneometer and Tewameter). Participants also reported subjective improvements. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2025.

The results after 12 weeks:

  • 93% of participants reported improved skin hydration
  • +38% improvement in forearm and upper arm hydration (corneometer)
  • +41% improvement in skin barrier on forearm and +35% on upper arm (tewameter)
  • 70% reported improved skin texture
  • 70% reported improved overall appearance

OS-01 EYE CREAM: 3-Month Efficacy Study3

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 3 months in 22 participants aged 47–65. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under-eye puffiness, and dark circles. The study has been published in the International Journal of Cosmetic Science.

Measured results:

  • +20 increase in hydration after 1 month; +32% increase in hydration after 3 months (Corenometer)
  • +14% increase in elasticity after 1 month; +26% increase in elasticity after 3 months (Cutometer)
  • +10% increase in firmness after 3 months (Cutometer)
  • +10% increase in barrier strength after 1 month; +17% increase in barrier strength after 3 months (Vapometer)

Consumer perception results:

  • 95% observed improved overall appearance after 3 months
  • 91% observed visibly more even tone and smoother texture after 3 months
  • 86% observed more radiant skin after 3 months
  • 82% observed visible improvements in firmness and elasticity after 3 months
  • 77% observed reduced visible eye puffiness after 3 months

OS-01 EYE CREAM: 12-Month Efficacy Study4

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 12 months in 23 participants aged 47–60. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily and results were assessed by expert clinical grading.

Expert Grading Results:

  • +19% increase in visible firmness after 6 months; +27% increase in visible firmness after 12 months (expert grading)
  • +23% increase in visible elasticity after 6 months; +29% increase in elasticity after 12 months (expert grading)
  • 18% reduction in the appearance of fine lines and wrinkles after 12 months (expert grading)

Consumer perception results:

  • 100% observed improved overall appearance after 12 months
  • 100% observed more radiant skin after 12 months
  • 96% observed visibly more even tone and smoother texture after 12 months
  • 95% observed improved firmness and elasticity after 12 months
  • 86% observed reduced appearance of eye bags after 12 months
  • 86% observed reduced appearance of visible dark spots after 12 months

Safety studies

OS-01 FACE RICH CREAM, OS-01 EYE CREAM, and OS-01 BODY MOISTURIZER are non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on their formulas and clinical testing, they have been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE RICH CREAM ingredients:
Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Nut Extract, Lauryl Olivate, Cetearyl Olivate, Euterpe Oleracea Fruit Oil, Squalane, C10-18 Triglycerides, Glyceryl Stearate SE, Linoleic/Oleic/Palmitic Triglyceride, Saccharide Isomerate, Sorbitan Olivate, Coconut Alkanes, 1,2-Hexanediol, Panthenol, Butyrospermum Parkii (Shea) Butter, Sodium PCA, Collagen Amino Acids, Ectoin, Citrullus Lanatus (Watermelon) Fruit Extract, Ceramide NP, Haematococcus Pluvialis Extract, Lens Esculenta (Lentil) Fruit Extract, Betaine, Coco-Caprylate/Caprate, Pyrus Malus (Apple) Fruit Extract, Moringa Oleifera Seed Oil, Decapeptide-52*, Hexapeptide-9, Tamarindus Indica Seed Polysaccharide, Limnanthes Alba (Meadowfoam) Seed Oil, Macadamia Integrifolia Seed Oil, Phytosphingosine, Sodium Lactate, Tremella Fuciformis Sporocarp Extract, Citric Acid, Sodium Citrate, Caprylyl Glycol, Phaeodactylum Tricornutum Extract, Cholesterol, Lecithin, Caprylhydroxamic Acid, Tocopherol, Propanediol, Sorbitan Oleate, Sorbitan Palmitate, Cetyl Palmitate, Dilinoleic Acid/Propanediol Copolymer, Sodium Phytate, Xanthan Gum, Cetearyl Alcohol, Hydroxyacetophenone, Sodium Benzoate.
*OS-01 Peptide™

OS-01 BODY MOISTURIZER ingredients:
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol.
*OS-01 Peptide™

OS-01 EYE CREAM ingredients:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide™

PREP FACIAL CLEANSER ingredients:
Water, Sodium Lauryglucosides Hydroxypropylsulfonate, Cocamidopropyl Hydroxysultaine, Disodium Lauryl Sulfosuccinate, Glycerin, Sodium Hydroxypropylphosphate Laurylglucoside Crosspolymer, Sodium Grapeseed Amidopropyl PG-Dimonium Chloride Phosphate, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Breu Branco Resin, Caprylyl Glycol, Phenoxyethanol, Lonicera Japonica (Honeysuckle) Flower Extract, Niacinamide, Sorbic Acid, Arnica Montana (Arnica Flower) Extract, Tetrasodium Glutamate Diacetate.

This set includes

STEP 1

PREP FACIAL CLEANSER

Gentle cleanser that exfoliates + removes impurities.

Size

50 mL / 1.7 fl oz

How to use

Dispense 1-2 pumps into damp hands and lather into a light foam. Gently massage onto face. Rinse and repeat 2x daily.

STEP 2

OS-01 EYE CREAM

Nourishing hydration that improves elasticity + firmness.

Size

7 mL / 0.24 fl oz

How to use

Dispense ½ to 1 pump onto fingertip, then tap around eyes in a semi-circle until absorbed. Use 2x daily.

STEP 3

OS-01 BODY MOISTURIZER

Nourishing hydration designed to strengthen crepey skin.

Size

60 mL / 2 fl oz

How to use

Apply to arms, legs, chest, back, and stomach and massage until absorbed. Use 2x daily.

STEP 4

OS-01 FACE RICH CREAM

Deep hydration clinically shown to firm, strengthen + replenish.

Size

15 mL / 0.5 fl oz

How to use

Smooth a generous layer onto clean, dry skin on the face, neck, and chest. Use 2x daily.

A metallic silver cosmetic pouch with a black zipper, featuring the debossed brand name 'ONE SKIN' in the center and an orange drawstring tag on the left side, set against a plain light gray background.

Signature Travel Bag

A dopp kit for your longevity skincare and travel necessities.

Size

0.8 gal / 5.1"H x 4.3"D x 8.3"W

How to clean

Hand wash and spot clean with a cool, damp cloth only—do not bleach, iron, tumble dry, or dry clean.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.5

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

LONGEVITY PROTOCOL DISCOVERY SET

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11,607 reviews
  • S
    Susan
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    5 minutes ago
    5 Stars

    Love it

    Was this helpful?
  • JM
    Joanna M.
    Verified Reviewer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    BODY MOISTURIZER

    Enjoying this moisturizer! Goes on so smooth and no greasy residue. I’m glad it has ingredients that help with creepiness as I am 61. Only been using for a few months but seeing improvement.

    Was this helpful?
  • JM
    Joanna M.
    Verified Buyer
    Reviewing
    PREP FACIAL CLEANSER
    I recommend this product
    Rated 5 out of 5 stars
    8 hours ago
    PREP FACIAL CLEANSER

    Love this cleanser! Like that it’s a pump. Cleans well and you don’t have to use a lot of the product like some other brands to get your face well cleansed.

    Was this helpful?
  • CW
    Christine W.
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    Face moisturizer

    Since using one skin moisturizer everyday on my face I’ve noticed a difference in my skin appearance and less discoloration.

    Was this helpful?
  • KE
    kathleen e.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Amazing products!

    I have been using one skin for a few years now and it is my routine. It has been great on mature skin, keeping it soft and supple. About to try the new advanced night cream too!

    Was this helpful?
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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
  2. Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025.)
  3. Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025.)
  4. Based on a third-party 12-month clinical study with 23 participants aged 47–60.
  5. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)