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Powered by Longevity Science

Younger, healthier skin starts at the cellular level

Meet OS-01, the first peptide proven to target a root cause of skin aging—cellular senescence.1

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OUR APPROACH

Led by science, not hype

Rigorous R&D platform

End-to-end product development run by our in-house team of scientists.

Scientifically validated claims

Quantified by our proprietary MolClock and Skin Age Modeling methods.

Ongoing clinical studies

Conducted by independent, third-party research organizations.

Peer-reviewed publications

The gold standard for scientific research and in skin care.

The real proof? It’s in the numbers.

9+
years of research
900+
peptides screened
18+
patents & publications
9000+
5-Star Reviews

OUR BREAKTHROUGH PEPTIDE

Think of OS-01 as a reset button for your skin, helping clear away the senescent cells that cause wrinkles, hyperpigmentation, and crepiness. As the first peptide scientifically proven to reduce cellular senescence in the skin, OS-01 does what other peptides can’t.1

6 visible signs of senescence

Lines and wrinkles

Caused by a decline in collagen and elastin production.

Loss of elasticity

Decreased elastin also contributes to lack of firmness.

Uneven skin tone

Irregular melanin production leads to hyperpigmentation.

Rough texture

Compromised skin cell renewal leaves a dry, uneven surface.

Loss of volume

Linked to a decrease in hyaluronic acid, collagen, and elastin.

Thinning skin

Slower cell turnover contributes to a weakened skin barrier.

Frequently Asked Questions

OneSkin

What are peptides?

Peptides are short chains of amino acids. They represent a broad class of molecules with many jobs, from forming the building blocks of larger proteins to acting as cellular messengers. Peptides found naturally in the body (called endogenous peptides), play a crucial role in tissue growth, hormone regulation, and other biological processes. Exogenous peptides, which can be injected, ingested or delivered topically like OS-01, can send out signals to skin cells to trigger collagen and hyaluronic acid production, aid in cellular repair, and help strengthen the skin barrier.01,02,03

How does OS-01 work?

OS-01 reduces the accumulation of senescent cells. These cells release inflammatory chemicals that cause neighboring cells to become dysfunctional, kicking off a domino effect in skin and accelerating skin aging. By reducing this inflammatory response, OS-01 helps prevent the accumulation of senescent cells in skin, improving key skin aging biomarkers and keeping other skin cells healthy and thriving.01,02,03

Who is OneSkin for?

OneSkin is for everyone. Whether you’re taking a preventative approach or want your skin’s health and appearance to reflect how you feel on the inside, our scientifically proven products work at the cellular level to keep your skin looking, feeling, and acting younger and healthier as you age.01,02,03

What skin concerns does OneSkin address?

Through lab studies and clinical studies, our products have been shown to combat the visible and invisible signs of aging, from collagen loss and thinning skin to a compromised barrier function.01,02,03

To learn more about the specific benefits of each product, visit oneskin.mom/claims.

How long does it take to see results?

With daily use, you can expect to see visible results within 12 weeks, though some people see changes even sooner. This time frame allows OS-01 to work at the cellular level, improving the long-term health and appearance of your skin.01,02,04

1Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
2Zonari A.,et al.Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation.J Cosmet Dermatol.2024; 23: 2135-2144. doi:10.1111/jocd.16242
3Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more atoneskin.mom/claims
4Zonari, A.,et al.Clinical efficacy of OS-01 Peptide™ formulation in reducing the signs of periorbital skin aging.Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

OneSkin
PHILANTHROPY

Propelled by a shared mission to
change the way humans experience aging

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We donate a portion of sales to the Aging Forward (formerly Shepherd's Center of America), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning.

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