OneSkin × Dave Asprey
Dave's longevity stack
“[Dave's approved quote about OS-01. One to two lines, in his words.]”
Dave Asprey
Author & Biohacker
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Skincare built on longevity science.
Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.
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10+
Years of research
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900+
Peptides screened
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15,000+
5-star reviews
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22+
Patents & publications
Clinically shown to deliver visibly smoother, firmer, more even-toned skin in 12 weeks.1
Exclusive for Dave Asprey's community
An extra 15% off with code ASPREY
Then $100 every 2 months. Cancel anytime.
- Free shipping on orders over
- Try it risk-free for 30 days
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Certified cruelty-free by The Leaping Bunny
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Approved by the National Eczema Association
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Certified plastic neutral in partnership with RePurpose
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Clinically Tested to Support the Skin Microbiome
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Certified cruelty-free by The Leaping Bunny
-
Approved by the National Eczema Association
-
Certified plastic neutral in partnership with RePurpose
-
Clinically Tested to Support the Skin Microbiome
-
Certified cruelty-free by The Leaping Bunny
-
Approved by the National Eczema Association
-
Certified plastic neutral in partnership with RePurpose
-
Clinically Tested to Support the Skin Microbiome
Dave's community saves an extra 15% with code ASPREY
The science
From cellular senescence to visible results.
The problem
Senescent “zombie” cells
With age and exposure to environmental stressors, cells enter a dysfunctional state known as senescence.
Often called “zombie cells,” senescent cells release inflammatory factors and enzymes that break down tissue and push neighboring healthy cells into premature senescence, triggering a cascade of cellular aging.
The mechanism
OS-01 Peptide™ targets senescence
Our proprietary OS-01 Peptide™ works at the cellular level to help keep healthy cells thriving.
In lab studies, the OS-01 Peptide™ reduces senescence in skin.2 It reduces SASP-secreting cells, slowing the spread and accumulation of senescence in skin.2
The result
Visibly firmer, smoother, stronger skin
+19% improvement in barrier strength1
86% showed reduced appearance of fine lines and wrinkles after 12 weeks1
96% had improved visible firmness, radiance, and tone after 12 weeks1
Your routine
Where OS-01 fits in your skincare stack.
Step 1 · AM + PM
Cleanse
Prepare your skin to receive maximum benefits of the OS-01 Peptide™ by using PREP then OS-01 FACE.
Step 2 · AM + PM
OS-01 FACE MOISTURIZER
Apply it after cleansing and before SPF for optimal OS-01 Peptide™ effect.
Gently massage into skin on the face and neck, morning and evening.
Step 3 · AM
SPF
To get the most benefit from the OS-01 Peptide™, we recommend applying OS-01 FACE first, followed by OS-01 FACE SPF.
Pairs well with
Your actives
OS-01 FACE MOISTURIZER has not been shown to produce adverse reactions with other common actives, including retinol, vitamin C, or hyaluronic acid.
Retinol increases sun sensitivity, so it should only be used at night. OS-01 can be used day and night.
[TODO: pairing guidance for exfoliating acids (AHA/BHA) and other peptides. None is published on oneskin.mom yet.]
As with any new skincare product, we recommend a patch test first.
Double-blind, vehicle-controlled clinical study
Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.1
Dave's OneSkin Protocol
Citations
- Based on a double-blind, third-party 12 week clinical study with 22 participants aged 54-64. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)
- Based on ex vivo and in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
[Regulatory disclaimer. Partner disclosure: Dave Asprey is a paid OneSkin partner, if applicable.]